Affiliations: [a] Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran | [b] Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Correspondence:
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Corresponding author: Mostafa Ghanei, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Tel.: +98 21 82483250; E-mail:mghaneister@gmail.com
Abstract: Airway Remodeling, a patho-physiologic process, is considered as a key
feature of chronic airway diseases. In recent years, our understanding of
the complex diseases has increased significantly by the use of combined
approaches, including systems biology, which may contribute to the
development of personalized and predictive medicine approaches. Integrative
analysis, along with the cooperation of clinicians, computer scientists,
research scientists, and bench scientists, has become an important part of
the experimental design and therapeutic strategies in the era of omics. The
airway remodeling process is the result of the dysregulation of several
signaling pathways that modulate the airway regeneration; therefore,
high-throughput experiments and systems biology approach can help to
understand this process better. The study reviews related literature and is
consistent with the existing clinical evidence.
Keywords: Airway remodeling, systems biology, clinical strategy
