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Construction of an anthropopathic abdominal phantom for accuracy validation of deformable image registration

Issue title: Papers from the 4th International Conference on Biomedical Engineering and Biotechnology (ICBEB2015), 18-21 August 2015, Shanghai, China ``New Paradigms for Biomedical Engineering and Biotechnology''

Article type: Research Article

Authors: Liao, Y.L. | Chen, H.B. | Zhou, L.H.* | Zhen, X.*

Affiliations: Department of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China

Correspondence: [*] Corresponding authors: L.H. Zhou and X. Zhen, Department of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, China. E-mail:smart@smu.edu.cn(LZ),xinzhen@smu.edu.cn(XZ)

Keywords: Three-dimensional deformable phantom, deformable image registration, PVC, phantom construction

DOI: 10.3233/THC-161200

Journal: Technology and Health Care, vol. 24, no. s2, pp. S717-S723, 2016

Published: 13 June 2016
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Abstract

The purpose of this study is to design and fabricate an anthropopathic abdominal phantom for accuracy evaluation of deformable image registration (DIR) algorithms in adaptive radiation therapy. The constructed deformable organs, including the liver, kidney, spleen and stomach, are made of mixture of polyvinyl chloride (PVC) and softener dioctyl terephthalate, while the rigid structures, i.e. vertebrae, are made of white cement. Relation between the PVC-softener blending ratio and organ CT number is studied, and three-dimensional printing technic is employed to create highly anthropopathic organs in terms of organ shape and density. Detailed steps for phantom construction, landmark point placement and choice of phantom ingredients and construction recipe are introduced. Preliminary results of the mechanical properties of the fabricated organs are also presented. The experimental results indicate that the constructed phantom has satisfactory elastic characteristics and close CT number with corporal organs, and can potentially be applied to simulate real abdominal organ deformation in geometric accuracy validation of DIR algorithms.

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