Matrix‐assisted laser desorption ionization and electrospray ionization combined with Fourier transform ion cyclotron resonance mass spectrometry

Article type: Review Article

Authors: Staneke, Paul O. | Nibbering, Nico M.M.

Affiliations: Institute of Mass Spectrometry, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands

Abstract: During recent years, matrix‐assisted laser desorption ionization (MALDI) and electrospray ionization (ESI) are successfully employed to analyze biomolecules and polymers. In combination with Fourier transform ion cyclotron resonance (FT‐ICR) mass spectrometry, high mass resolution and mass measurement accuracy can be achieved to enable the determination of molecular weights and structural characterization of biochemical compounds larger than 10 kDa.

Journal: Spectroscopy, vol. 13, no. 2, pp. 145-150, 1997