Biomedical application of Mössbauer spectroscopy with a high velocity resolution: Revealing of small variations

Article type: Research Article

Authors: Oshtrakh, M.I.^; | Semionkin, V.A.^; | Milder, O.B.^; | Alenkina, I.V.^; | Novikov, E.G.^;

Affiliations: Faculty of Physical Techniques and Devices for Quality Control, Physical–Technical Department, Ural Federal University, Ekaterinburg, Russian Federation | Faculty of Experimental Physics, Physical–Technical Department, Ural Federal University, Ekaterinburg, Russian Federation | Radio–Technical Department, Ural Federal University, Ekaterinburg, Russian Federation

Note: [] Corresponding author: M.I. Oshtrakh, Faculty of Physical Techniques and Devices for Quality Control, Physical–Technical Department, Ural Federal University, Ekaterinburg, Russian Federation. E-mail: oshtrakh@mail.utnet.ru.

Abstract: Application of Mössbauer spectroscopy with a high velocity resolution for study different hemoglobins, ferritin, its models and chicken liver and spleen as well as normal and lymphoid chicken spleen demonstrated revealing of small variations of hyperfine parameters related to small variations of iron stereochemistry in biomolecules. These data demonstrate that Mössbauer spectroscopy with a high velocity resolution may be useful in biomedical research to distinguish small variations of iron-containing proteins in normal and pathological cases.

Keywords: Mössbauer spectroscopy with a high velocity resolution, biomedical applications, small variations

DOI: 10.3233/SPE-2010-0489

Journal: Spectroscopy, vol. 24, no. 6, pp. 593-599, 2010