Affiliations: Department of Chemistry, Nanjing Xiaozhuang University, Nanjing, P. R. China
Note: [] Corresponding author: Changyun Chen, Department of Chemistry, Nanjing Xiaozhuang University, Nanjing 210017, P. R. China. Tel.: +86 25 86178262; E-mail: chenchangyunjyh@yahoo.com.cn.
Abstract: A novel complex Sm(III) complex with ofloxacin was synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, thermal analysis (TG-DSC), 1H-NMR spectra. Then, spectrometric titration, ethdium bromide displacement experiments by UV spectroscopy, ionic influence, viscosity measurements and Circular Dichroism (CD) spectroscopic measurements were conducted to characterize the interaction between the complex and CT-DNA. Results obtained indicate that the complex bound with CT-DNA via an intercalation mechanism. The binding constants and binding sites number of the Sm(III) complex with CT-DNA were 1.80×105 l·mol−1 and 1, respectively.
Keywords: Sm complex with ofloxacin, structural characterization, DNA-binding properties
DOI: 10.3233/SPE-2009-0378
Journal: Spectroscopy, vol. 23, no. 2, pp. 103-111, 2009
