Affiliations: Department of Physics, Lucknow University, 226007, India | Department of Physics, Mahila PG College, Aminabad, Lucknow, India | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India
Note: [] Corresponding author: Neeraj Misra, Department of Physics, Lucknow University, 226007, India. E-mail: misraneeraj@gmail.com
Abstract: A complete normal coordinate analysis was performed for andrographolide in terms of the calculation by using Wilson's G-F matrix method and Urey Bradley force field. Normal coordinate analysis has been carried out to understand the dynamical behaviour of the bioactive labdane diterpenoid of the medicinally useful terrestrial plant Andrographis paniculata. The structural elucidation of a novel, biologically active natural product followed by its total synthesis lays the groundwork for investigations into its biological mechanism of action including putative cellular receptor isolation.
Keywords: FT-IR spectra, diterpene, normal coordinate analysis
Journal: Spectroscopy, vol. 20, no. 5-6, pp. 275-283, 2006
