Affiliations: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA | Mass Consortium Corporation, 3030 Bunker Hill Street, San Diego, CA 92109, USA | Pfizer Global Research and Development – La Jolla Laboratories, Agouron Pharmaceuticals, Inc., 10770 Science Center Drive, San Diego, CA 92121, USA | Waters Corporation, 34 Maple Street, Milford, MA 01757, USA