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Article type: Research Article
Authors: Kerns, James M. | Pavkovic, Ivan M. | Fakhouri, Anton J. | Gray, George T.
Affiliations: Department of Anatomy, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA | American College of Testing, Iowa City, IA, USA
Note: [] Correspondence: J.M. Kerns, Department of Anatomy, Rush-Presbyterian-St. Luke's Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA. Fax: (1)(312) 942 2333.
Abstract: The effect of D.C. electrical fields on in vivo nerve regeneration following rat sciatic nerve transection was assessed by a toe-twitch tension method for motor recovery. Two groups for baseline comparisons received either a nerve transection and a neutral battery implant or a nerve crush and no implant. Two treatment groups each received a nerve transection and an implant delivering either cathodal (–10 μA) or anodal (+10 μA) current via electrodes positioned on either side of the transection site. The contralateral nerve was exposed but not given a lesion. The functional recovery was assessed at weekly intervals by comparing the amplitude and area of the twitch tension curves on both sides, expressed as a ratio (index of motor recovery = IMR). By 28–35 days postoperative (dpo) the crushed/untreated group had mean IMR values not significantly different than the preoperative values. The transected/neutral group appeared to have the worst recovery throughout the study. Compared to these two groups, both the cathodal and anodal treatment groups with a transected nerve showed intermediate IMR values, but by 63 dpo the group differences were less. These results indicate that following a nerve transection lesion steady D.C. electrical fields may temporarily enhance the early functional recovery of motor nerve regeneration compared to conventional nerve repair alone.
Keywords: Direct current, Electrical stimulation, Implantable stimulator, Nerve regeneration, Twitch tension
DOI: 10.3233/RNN-1994-6301
Journal: Restorative Neurology and Neuroscience, vol. 6, no. 3, pp. 175-180, 1994
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