Affiliations: Department of Medicine (Neurology) and Center for Health Policy Research and Education, Duke University, Durham, NC (USA) and Department of Veterans' Affairs Medical Center, Durham, NC (USA) | Department of Medicine (Neurology), University of Toronto, Toronto, ON M5G 2C4 (Canada)
Note: [] Correspondence: L.B. Goldstein, Box 3651, Duke University Medical Center, Durham, NC 27710, USA. Fax: (1)(919) 684 6514.
Abstract: Pharmacologic studies have implicated norepinephrine in amphetamine-facilitated motor recovery following sensorimotor cortex injury in rats. We studied the acute effects of unilateral sensorimotor cortex ablation on the release of norepinephrine in cerebellum with in vivo dialysis. In rats without a cortex lesion, the administration of a single dose of d-amphetamine (2.6 mg/kg base weight, i.p.) resulted in a substantial increase in dialyzable norepinephrine in cerebellum reaching its peak 30–40 min later (∼ 14 pg/μl, not corrected for recovery). The administration of the same dose of d-amphetamine to rats 60 min following a suction-ablation lesion of the right sensorimotor cortex did not result in norepinephrine release into the cerebellar dialysates. These data provide evidence for an acute remote effect of sensorimotor cortex injury on amphetamine-induced norepinephrine release in the cerebellum (diaschisis).
Keywords: Diaschisis, Norepinephrine, Sensorimotor cortex, Cerebellum, Microdialysis, Rat
