Affiliations: Brain Research Laboratory, Institute of Animal Behavior, Rutgers, The State University of New Jersey, Newark, NJ 07102 (USA)
Note: [] Correspondence: R.L. Roof, Brain Research Laboratory, Institute of Animal Research, Rutgers, The State University, 101 Warren St., Newark, NJ 07102, USA. Fax: (1)(201) 648-1102.
Abstract: To assess the effectiveness of progesterone as a treatment for edema following traumatic brain injury, male and female rats were injected with progesterone or the oil vehicle over a 3-day period following a cortical contusion injury. Oil-treated rats showed significant localized edema as measured by the wet weight/dry weight tissue punch technique. Progesterone-treated rats, both male and female, showed marked attenuation, or in some cases, absence of this post-injury edema. We conclude that progesterone shows promise as a treatment for edema following traumatic brain injury.
