Collagen-cliondroitin-6-sulfate hydrogel implants in CNS lesion cavities favor glial repair, the differentiation of co-implanted neurons and the growth of axons

Article type: Short Communication

Authors: Woerly, Stéphane | Marchand, Raymond

Affiliations: Centre de recherche en neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Que. (Canada)

Note: [] Correspondence: R. Marchand, Centre de recherche en neurobiologie, Hôpital de 1'Enfant-Jésus, 1401, 18e rue Québec, Que., Canada G1J JZ4.

Abstract: Collagen chondroitin-6-sulfate hydrogels containing embryonic striatal neurons were implanted into premade brain cavities of the rat striatum. The bioimplant was progressively transformed into a new matrix mostly by the deposition of newly formed collagen and by the ingrowth of glial cells and glial cell processes. At two months, the new matrix has partly restructured the lesion cavity. Cells co-implanted with the hydrogels attached, survived and differentiated while nerve fibers of the host striatum grew into the biomatrix.

Keywords: Collagen matrix, Chondroitin sulfate, Neural graft, Regeneration, Astrocyte, Glial repair

DOI: 10.3233/RNN-1991-3206

Journal: Restorative Neurology and Neuroscience, vol. 3, no. 2, pp. 95-99, 1991