Effects of an evidence-based nursing intervention on neurological function and serum inflammatory cytokines in patients with acute cerebral infarction: A randomized controlled trial

Article type: Research Article

Authors: Liu, Yaping^{a; *} | Qu, Mingwei^a | Wang, Nan^b | Wang, Limin^a

Affiliations: [a] Department of Neurology, Cangzhou Central Hospital, Cangzhou, Hebei, China | [b] Party Office, Cangzhou Central Hospital, Cangzhou, Hebei, China

Correspondence: [*] Corresponding author: Yaping Liu, Department of Neurology, Cangzhou Central Hospital, No. 16, Xinhua West Road, Cangzhou 061000, Hebei, China. Tel.: +86 15931722915; E-mail: Liuyaping870107@163.com.

Abstract: Background:Acute cerebral infarction is a clinically common and critical disease which seriously endangers the life and safety of elderly patients. Evidence-based nursing is an effective way of nursing and has great significance in improving the neurological function and quality of life of patients. In China, evidence-based nursing has been highlighted and highly developed in recent decades. Objectives:This research aimed to investigate the effect of evidence-based nursing on the recovery of neurological function and serum inflammatory cytokines in patients with acute cerebral infarction. Methods:A total of 116 patients with acute cerebral infarction were randomly divided into two groups: the control group patients (n = 58) received conventional nursing, while the intervention group patients (n = 58) received evidence-based nursing intervention. National Institutes of Health Stroke Scale (NIHSS), Fugl-Meyer assessment (FMA) and activities of daily living (ADL) scores, as well as serum TNF-α and IL-6 levels were evaluated and compared between the two groups. Results:NIHSS scores in the intervention group were significantly lower than the control group. FMA and ADL scores in the intervention group were significantly higher than the control group. TNF-α and IL-6 levels in the serum of the intervention group were significantly lower than the control group. Conclusions:In conclusion, evidence-based nursing has a positive effect on the treatment of patients with acute cerebral infarction, which decreases the level of serum inflammatory cytokines and contributes to the recovery of neurological function, motor function and activities of daily living.

Keywords: Acute cerebral infarction, evidence-based nursing, TNF-α , IL-6, quality of life, neurological function

DOI: 10.3233/RNN-201080

Journal: Restorative Neurology and Neuroscience, vol. 39, no. 2, pp. 129-137, 2021