Efficacy of coupling intermittent theta-burst stimulation and 1 Hz repetitive transcranial magnetic stimulation to enhance upper limb motor recovery in subacute stroke patients: A randomized controlled trial

Article type: Research Article

Authors: Meng, Ying | Zhang, Dai | Hai, Hong | Zhao, Ying-Yu | Ma, Yue-Wen^{; *}

Affiliations: Department of Rehabilitation Medicine, the First Affiliated Hospital of China Medical University, Shenyang, China

Correspondence: [*] Corresponding author: Yue-Wen Ma, Ph.D., Professor, Department of Rehabilitation Medicine, the First Hospital of China Medical University, Shenyang, China. Tel.: +86 02483282573; Fax: +86 02483283568; E-mail: yuewen_m@126.com.

Abstract: Background:Both 1 Hz repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are reported to benefit upper limb motor function rehabilitation in patients with stroke. However, the efficacy of combining 1 Hz rTMS and iTBS has not been adequately explored. Objective:We aimed to compare the effects of 1 Hz rTMS and the combination of 1 Hz rTMS and iTBS on the upper limb motor function in the subacute phase post-stroke. Methods:Twenty-eight participants were randomly assigned to three groups: Group A (1 Hz rTMS over the contralesional primary motor cortex (M1) and iTBS over the ipsilesional M1), Group B (contralesional 1 Hz rTMS and ipsilesional sham iTBS), and Group C (contralesional sham 1 Hz rTMS and ipsilesional sham iTBS). The participants received the same conventional rehabilitation accompanied by sessions of transcranial magnetic stimulation for two weeks (5 days one week). Motor-evoked potential (MEP), upper extremity Fugl-Meyer Assessment (UE-FMA), and Barthel Index (BI) were performed before and after the sessions. Results:Group A showed greater UE-FMA, BI, and MEP amplitude improvement and more significant decrement in MEP latency compared to Group B and Group C in testable patients. Correlation analyses in Group A revealed a close relation between ipsilesional MEP amplitude increment and UE-FMA gain. Conclusions:The combining of 1 Hz rTMS and iTBS protocol in the present study is tolerable and more beneficial for motor improvement than the single use of 1 Hz rTMS in patients with subacute stroke.

Keywords: Transcranial magnetic stimulation, stroke, rehabilitation

DOI: 10.3233/RNN-190953

Journal: Restorative Neurology and Neuroscience, vol. 38, no. 1, pp. 109-118, 2020