Cholinergic potentiation of visual perception and vision restoration in rodents and humans

Issue title: Low Vision: Rescue, Regeneration, Restoration and Rehabilitation

Guest editors: Andrea Antal and Bernhard Sabel

Article type: Research Article

Authors: Vaucher, Elvire^{a; b; *} | Laliberté, Guillaume^a | Higgins, Marie-Charlotte^a | Maheux, Manon^{b; c} | Jolicoeur, Pierre^{b; c} | Chamoun, Mira^a

Affiliations: [a] Laboratoire de Neurobiologie de la Cognition Visuelle, École d’optométrie, Université de Montréal, Montréal, Québec, Canada | [b] Centre de recherche en neuropsychologie et cognition (CERNEC), Montréal, Québec, Canada | [c] Département de Psychologie, Université de Montréal, Montréal, Québec, Canada

Correspondence: [*] Corresponding author: Elvire Vaucher, PhD, Laboratoire de Neurobiologie de la Cognition Visuelle, École d’optométrie, Université de Montréal, CP 6128, succ. Centre-ville, Montréal, Québec, H3C 3J7, Canada. Tel.: +1 5143437537; E-mail: elvire.vaucher@umontreal.ca.

Abstract: Background:The cholinergic system is a potent neuromodulator system that plays a critical role in cortical plasticity, attention, and learning. Recently, it was found that boosting this system during perceptual learning robustly enhances sensory perception in rodents. In particular, pairing cholinergic activation with visual stimulation increases neuronal responses, cue detection ability, and long-term facilitation in the primary visual cortex. The mechanisms of cholinergic enhancement are closely linked to attentional processes, long-term potentiation, and modulation of the excitatory/inhibitory balance. Some studies currently examine this effect in humans. Objective:The present article reviews the research from our laboratory, examining whether potentiating the central cholinergic system could help visual perception and restoration. Methods:Electrophysiological or pharmacological enhancement of the cholinergic system are administered during a visual training. Electrophysiological responses and perceptual learning performance are investigated before and after the training in rats and humans. This approach’s ability to restore visual capacities following a visual deficit induced by a partial optic nerve crush is also investigated in rats. Results:The coupling of visual training to cholinergic stimulation improved visual discrimination and visual acuity in rats, and improved residual vision after a deficit. These changes were due to muscarinic and nicotinic transmissions and were associated with a functional improvement of evoked potentials. In humans, potentiation of cholinergic transmission with 5 mg of donepezil showed improved learning and ocular dominance plasticity, although this treatment was ineffective in augmenting the perceptual threshold and electroencephalography. Conclusions:Potential therapeutic outcomes ought to facilitate vision restoration using commercially available cholinergic agents combined with visual stimulation in order to prevent irreversible vision loss in patients. This approach has the potential to help a large population of visually impaired individuals.

Keywords: Acetylcholine, attention, cholinesterase inhibitor, cholinergic system, cortical plasticity, donepezil, perceptual learning, visual cortex

DOI: 10.3233/RNN-190947

Journal: Restorative Neurology and Neuroscience, vol. 37, no. 6, pp. 553-569, 2019