Affiliations:
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada and Jewish General Hospital with Lady Davis Institute for Medical Research, Montreal, QC, Canada
Correspondence:
[*]
Corresponding author: Alexander Thiel, MD, Professor Neurology and Neurosurgery, Department of Neurosciences, Jewish General Hospital, 3755 Chemin de la Côte Sainte-Catherine, Montreal, QC, H3T1E2, Canada. Tel.: +1 514 340 8222 Ext. 5844; Fax: +1 514 340 7567; E-mail: alexander.thiel@mcgill.ca.
Correspondence:
[*]
Corresponding author: Anna Zumbansen, PhD, Jewish General Hospital, 3755 Chemin de la Côte Sainte-Catherine, Montreal, QC, H3T1E2, Canada. Tel.: +1 514 340 8222 Ext. 4311; Fax: +1 514 340 7567; E-mail: anna.zumbansen@mail.mcgill.ca.
Abstract: Background: Post-stroke aphasia syndromes as a clinical entity arise from the disruption of brain networks specialized in language production and comprehension due to permanent focal ischemia. This approach to post-stroke aphasia is based on two pathophysiological concepts: 1) Understanding language processing in terms of distributed networks rather than language centers and 2) understanding the molecular pathophysiology of ischemic brain injury as a dynamic process beyond the direct destruction of network centers and their connections. While considerable progress has been made in the past 10 years to develop such models on a systems as well as a molecular level, the influence of these approaches on understanding and treating clinical aphasia syndromes has been limited. Objective & Methods: In this article, we review current pathophysiological concepts of ischemic brain injury, their relationship to altered information processing in language networks after ischemic stroke and how these mechanisms may be influenced therapeutically to improve treatment of post-stroke aphasia. Conclusion: Understanding the pathophysiological mechanism of post-stroke aphasia on a neurophysiological systems level as well as on the molecular level becomes more and more important for aphasia treatment, as the field moves from standardized therapies towards more targeted individualized treatment strategies comprising behavioural therapies as well as non-invasive brain stimulation (NIBS).
Keywords: Aphasia, ischemic stroke, language network, pathophysiology of stroke, speech and language therapy, transcranial magnetic stimulation, transcranial direct current stimulation
