Effects of human growth hormone on peripheral nerve regeneration

Issue title: Regulators of Peripheral Nerve Regeneration

Article type: Research Article

Authors: Skottner, Anna | Kanje, Martin | Arrhenius-Nyberg, Vibeke | Lundborg, Göran

Affiliations: Kabi Peptide Hormones, Stockholm (Sweden) | Department of Zoophysiology, University of Lund, Lund (Sweden)

Note: [] Correspondence: A. Skottner, Kabi Peptide Hormones, Lindhagensgatan 133, S-11297 Stockholm, Sweden.

Abstract: Systemic administration of human growth hormone (hGH) to intact or hypophysectomized rats was found to stimulate regeneration of the crush-lesioned sciatic nerve. The IGF-I levels of serum of the treated rats did not correlate with regeneration of the nerve but hGH treatment increased the IGF-I content of the nerve. The results suggest that a GH-mediated increase of IGF-I in the sciatic nerve could be involved in the stimulatory effect of GH on neurite outgrowth.

Keywords: Human growth hormone, Insulin-like growth factors, Sciatic nerve, In vivo, Regeneration, Rats

DOI: 10.3233/RNN-1990-13409

Journal: Restorative Neurology and Neuroscience, vol. 1, no. 3-4, pp. 233-235, 1990