Insulin-like growth factor I (IGF-I) and regeneration of the sciatic nerve of the rat

Issue title: Regulators of Peripheral Nerve Regeneration

Article type: Research Article

Authors: Kanje, Martin | Skottner, Anna | Sjöberg, Jacob

Affiliations: Department of Zoophysiology, University of Lund, Lund (Sweden) | Kabi Peptide Hormones, Stockholm (Sweden)

Note: [] Correspondence: M. Kanje, Department of Zoophysiology, University of Lund, Helgonav 3 B, S-223 62 Lund, Sweden.

Abstract: We have found that insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve. This paper reviews and adds some new data to our investigations on the effects of local administration of IGF-I to the sciatic nerve after infliction of a crush or freeze injury.

Keywords: Insulin-like growth factors, Somatomedins, Peripheral nerve, Sciatic nerve, Rat, Regeneration

DOI: 10.3233/RNN-1990-13406

Journal: Restorative Neurology and Neuroscience, vol. 1, no. 3-4, pp. 211-215, 1990