Affiliations: Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029 (India) | Department of, Anatomy, All India Institute of Medical Sciences, New Delhi 110029 (India) | Department of, Neurosurgery, All India Institute of Medical Sciences, New Delhi 110029 (India)
Note: [] Correspondence: V. Mohan Kumar, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
Abstract: Kainic acid lesion of the medial preoptic area resulted in the impairment of the thermoregulation and disruption of the reproductive cycle in female rats. The preoptic–anterior hypothalamic area from fetal donor was transplanted into the lesioned area ofthe host. After transplantation, these animals showed signs of estrus cyclicity and a recovery in basal temperature towards normal. They also showed a reduced shift of body temperature on exposure to a hot environment. Thus the female rats, which received transplantation, showed some degree of recovery of functions which were disrupted by kainic acid lesions.
