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Issue title: Brain Stimulation and Brain Repair – rTMS
Article type: Research Article
Authors: Cazzoli, Dario | Müri, René M. | Hess, Christian W. | Nyffeler, Thomas
Affiliations: Perception and Eye Movement Laboratory, Department of Neurology, Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland
Note: [] Corresponding author: Th. Nyffeler, MD; Perception and Eye Movement Laboratory, Department of Neurology, Department of Clinical Research, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland. Tel.: +41 31 632 30 83; Fax: +41 31 632 97 70; E-mail: thomas.nyffeler@insel.ch
Abstract: Hemispatial neglect – defined as the failure to attend, explore, and act upon the contralesional side of space – is a frequent and disabling neurological syndrome. Interhemispheric rivalry is considered as a major pathophysiological mechanism underlying hemispatial neglect. According to this account, the contralesional, intact hemisphere undergoes a pathological hyperactivity due to a deficient transcallosal inhibition from the damaged hemisphere. This model offers a framework for possible therapeutic interventions with repetitive transcranial magnetic stimulation (rTMS), i.e. a reduction of the pathological hyperactivity with a rTMS protocol that has lasting inhibitory effects. In the present work, we will first review evidence for the interhemispheric rivalry account coming from animals and humans. We will then describe studies showing the possibility to perturb and to restore interhemispheric balance in healthy subjects as a proof of concept for therapeutic rTMS application. Finally, we will consider studies applying rTMS as a therapeutic approach in hemispatial neglect. We conclude that rTMS is a promising approach to reduce the interhemispheric imbalance in neglect patients and to ameliorate symptoms. Newly developed protocols such as Theta Burst Stimulation (TBS) – with short stimulation times and long offline effects – seem to be particularly convenient. However, future studies should assess stimulation effects not only in clinical testing, but also on disability, considering combination with traditional therapies as well.
Keywords: Hemispatial neglect, experimental therapy, interhemispheric balance, visuospatial attention, repetitive transcranial magnetic stimulation, Theta Burst Stimulation
DOI: 10.3233/RNN-2010-0560
Journal: Restorative Neurology and Neuroscience, vol. 28, no. 4, pp. 499-510, 2010
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