Affiliations: Department of Neurosciences, University of California
San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0691, USA
Note: [] Correspondence author: Binhai Zheng, Ph.D., Assistant Professor,
Department of Neurosciences, University of California San Diego, 9500 Gilman
Drive, MC 0691, La Jolla, CA 92093-0691, USA. Tel.: +1 858 534 5807; Fax: +1
858 822 1021; E-mail: binhai@ucsd.edu
Abstract: The use of genetically modified mice to study axon regeneration
after spinal cord injury has served as a useful in vivo model for both
loss-of-function and gain-of-function analysis of candidate proteins. This
review discusses the impact of genetically modified mice on axon regeneration
after spinal cord injury in the context of axon growth inhibition by myelin,
the glial scar, and chemorepellent molecules. We also discuss the use of mice
which transgenically express fluorescent proteins in specific axons for
increasing our understanding of how spinal cord axons behave after injury.
