Affiliations: Neural Plasticity Laboratory, Instituto Cajal, CSIC,
Avenida del Doctor Arce, 37, 28002 Madrid, Spain
Note: [] Corresponding author: Manuel Nieto-Sampedro, Instituto Cajal,
CSIC, Avenida del Doctor Arce, 37, Madrid 28002, Spain. Tel.: +341 585 4720;
Fax: +341 585 4754; E-mail: mns@cajal.csic.es
Abstract: The lamination of dentate gyrus afferents established during
development is maintained following lesion-induced reactive growth in the
adult. After partial deafferentation sprouts from undamaged afferents restore
most synapses, while respecting the laminae relative boundaries. No evidence of
trans-laminar sprouting has been found. Here, we review the information
gathered during the last decade on the cellular and molecular bases of dentate
synaptogenesis, with special attention to the role of glia during development
and that of reactive glia after deafferentation. The interactions of neurons
with astroglia and astroglial macromolecules, particularly proteoglycans,
influence synapse segregation in the dentate gyrus, providing us with a
reasonable explanation for afferent lamination.
