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Naringin at a nutritional dose modulates expression of genes related to lipid metabolism and inflammation in liver of mice fed a high-fat diet

Article type: Research Article

Authors: Chanet, Audrey | Wizinska, Patrycja; | Polakof, Sergio | Mazur, Andrzej | Bennetau-Pelissero, Catherine | Morand, Christine | Bérard, Annie M. | Milenkovic, Dragan

Affiliations: INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand, France | Université de Bordeaux – ENITA Bordeaux 1, Gradignan Cedex, France | ERU “Facteurs de risque vasculaires”, CHU-Université de Bordeaux, Bordeaux, France | Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland

Note: [] Corresponding author: Christine Morand, INRA centre de recherche de Clermont-Ferrand/Theix, Unité de Nutrition Humaine (UNH), Equipe Micronutriments, métabolisme et santé (MiMeS), 63 122 Saint-Genès-Champanelle, France. Tel.: +33 (0)4 73 62 40 84; E-mail: christine.morand@clermont.inra.fr

Note: [] Corresponding author: Annie M. Bérard, CHU-Université Bordeaux, ERU “Facteurs de risque vasculaires”, case 49, 146 rue Léo Saignat, 33076 Bordeaux, France. Tel.: +33 (0)5 56 79 56 79; Extension 14616; E-mail: annie.berard@u-bordeaux2.fr

Keywords: Naringin, liver, high-fat high-cholesterol diet, hypercholesterolemic mouse model, transcriptomic

DOI: 10.3233/NUA-2012-0010

Journal: Nutrition and Aging, vol. 1, no. 2, pp. 113-123, 2012

Published: 2012
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Abstract

Epidemiological and clinical studies a role for flavanones (predominately found in citrus fruits) in the prevention of cardiovascular disease. Previously, we have shown that a nutritional dose of naringin exerts anti-atherogenic properties together with non HDL-cholesterol lowering effect in a murin model of dietary-induced hypercholesterolemia [1]. The goal of the present study was to explore possible molecular mechanisms of naringin at the hepatic level. To this end, we analyzed the hepatic transcriptome using a microarray approach in response to naringin supplementation (0.02%) in mice fed a high-fat high-cholesterol diet. Naringin was observed to increase hepatic lipid content (triglyceride and cholesterol) without significant liver dysfunction (ALAT and ASAT activities) or histopathological alterations. Naringin supplementation also significantly improved insulin sensitivity as evaluated by the HOMA index and nutrigenomics revealed that naringin modulated the expression of 1,766 genes. These genes encode proteins involved in different cellular processes, such as lipid metabolism, inflammation and insulin signaling. In conclusion, this study revealed that the hypolipemic and anti-atherogenic effects induced by a nutritional-level naringin supplementation in high-fat high-cholesterol diet could be related to changes in hepatic lipid metabolism and inflammatory response, revealing new in vivo targets of this flavanone.