Comparative neuroimaging in children with cerebral palsy using fMRI and a novel EEG-based brain mapping during a motor task – A preliminary investigation
Affiliations: [a] Movement Healing Laboratory, Department of Physical Therapy, Yonsei University, Wonju, Republic of Korea | [b] Department of Physical Therapy, College of Health and Welfare, Woosong University, Daejeon, Republic of Korea | [c] Department of Radiological Science, Yonsei University, Wonju, Republic of Korea
Correspondence:
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Address for correspondence: Sung (Joshua) Hyun You, PT, PhD, Movement Healing Lab, Department of Physical Therapy, Yonsei University, 234 MaeJi-Ri, Heungup-Myon, Wonju City, Kangwon-do 220-710, Republic of Korea. Tel.: +82 33 760 2476; E-mail: neurorehab@yonsei.ac.kr
Note: [1] Both Jae Jin Lee and Dong Ryul Lee have equally contributed to the study as first coauthors.
Abstract: Purpose:The purpose of this study was to compare topographical maps using a novel EEG-based brain mapping system with fMRI in normal and children with cerebral palsy (CP) during a grasping motor task. Method:A normal child (mean ± SD = 13 ± 0 yrs) and four children with CP (mean ± SD = 10.25 ± 2.86 yrs) were recruited from a local community school and medical center. A novel EEG-based brain mapping system with 30 scalp sites (an extension of the 10–20 system) and a 3T MR scanner were used to observe cortical activation patterns during a grasping motor task. Design:Descriptive analysis. Results:In the EEG brain mapping data, the sensorimotor cortex (SMC) and inferior parietal cortex (IPC) were activated in all of the children. The children with CP showed additional activation areas in the premotor cortex (PMC), superior parietal cortex (SPC), and prefrontal cortex (PFC). In the fMRI brain mapping data, SMC activation was observed in all of the children, and the children with CP showed additional activation areas in the PMC and primary somatosensory cortex (PSC). Discussion:The EEG-based topographical maps were equivalent to the maps obtained from fMRI during the grasping motor task. The results indicate that our novel EEG-based brain mapping system is useful for probing cortical activation patterns in normal children and children with CP.
