The effects and efficacy of cognitive enhancing substances in the treatment of Alzheimer's disease

Article type: Research Article

Authors: Kolakowsky-Hayner, Stephanie A.^{; *} | Hoffman, Beth | Metz, Stacie M. | Parente, Rick

Affiliations: Towson State University, Baltimore, MD 21204, USA

Correspondence: [*] Department of Physical Medicine and Rehab., Box 980542, Richmond, VA 23298-0542, USA. Tel.: +1 804 828 3702; Fax: +1 804 828 2378; E-mail: sakolako@hsc.vcu.edu

Abstract: In the past 30 years, literally hundreds of cognitive enhancing substances have been investigated. This large body of research has produced mixed results and there is no consensus as to whether these substances actually enhance cognition. Furthermore, little systematic evidence is available that documents whether or not these substances are efficacious treatments for Alzheimer's disease. This review summarizes findings of well-controlled clinical studies, provides a brief discussion of current therapeutic approaches for the treatment of Alzheimer's disease, discusses research regarding cognitive enhancing substances, and draws impartial conclusions concerning the efficacy of cognitive enhancing substances for the treatment of Alzheimer's disease.

Keywords: cognitive enhancing drugs, Alzheimer's disease

DOI: 10.3233/NRE-1999-12305

Journal: NeuroRehabilitation, vol. 12, no. 3, pp. 187-200, 1999