Extracellular superoxide dismutase levels in preeclampsia

Article type: Research Article

Authors: Kharb, Simmi^a

Affiliations: [a] Department of Biochemistry, Pt. BDS PGIMS, 1447, Sector-1, Urban Estate, Rohtak 124001, Haryana, India. e-mail: simmikh@rediffmail.com

Abstract: The present study was planned to study extracellular superoxide dismutase (EC-SOD) activity in 30 preeclamptic women, 30 normotensive pregnant and 30 non-pregnant women. EC-SOD activity was lower in normotensive pregnant women as compared to non-pregnant women (p < 0.05). The activity was still lower in preeclamptic women as compared to healthy pregnant and non-pregnant women (p < 0.001). These findings indicate a role of EC-SOD in modulating nitric oxide-dependent relaxation of the uterus and the development of hypertension as a predominant symptom in preeclampsia.

Keywords: Preeclampsia, Superoxide dismutase, Antioxidant

DOI: 10.3233/s12349-011-0069-4

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 5, no. 1, pp. 53-55, 2012