Oxidative stress modulation in neurodegenerative diseases

Article type: Research Article

Authors: Carlesi, C.^a | Caldarazzo Ienco, E.^a | Piazza, S.^a | Lo Gerfo, A.^a | Alessi, R.^a | Pasquali, L.^a | Siciliano, Gabriele^a

Affiliations: [a] Department of Neuroscience, Neurological Clinic, University of Pisa, via Roma, 67 56126 Pisa, Italy. e-mail: g.siciliano@med.unipi.it

Abstract: The primary pathological feature of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis is the slow and progressive selective dysfunction and loss of neurons and axons in the central nervous system. Despite different triggering events, a common feature is the involvement of oxidative stress. Several evidences indicate that oxidative stress is critical for neurodegeneration. Here, we review the impact of oxidative stress involvement in neurodegenerative disorders, and discuss its contribution to neurons damage. We also discuss potential antioxidant therapies to modulate oxidative stress in this group of diseases. A better understanding of the imbalance between the production of reactive oxygen species and the ability of nervous system to remove them or repair the ensuing damage will be crucial for the development of new potential therapeutic strategies.

Keywords: Antioxidant therapy, Neurodegeneration, Oxidative stress, Oxidative stress markers

DOI: 10.3233/s12349-011-0053-z

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 4, no. 3, pp. 219-225, 2011