Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Vahid, Farhada | Nasiri, Zahrab | Abbasnezhad, Amirc | Moghadam, Ezatollah Fazelic; *
Affiliations: [a] Nutrition & Health Group, Population Health Department, Luxembourg Institute of Health, Strassen, Luxembourg | [b] School of Medicine, Arak University of Medical Sciences, Arak, Iran | [c] Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Correspondence: [*] Corresponding author: Ezatollah Fazeli Moghadam, Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Tel.: +98 916 666 3374; E-mail: ztfazeli@yahoo.com.
Abstract: BACKGROUND:Oxidative stress and chronic inflammation are among the leading causes of coronary heart disease (CHD). Studies investigated the relationship between dietary antioxidants and the risk/odds of CHD, and contradictory results have been reported. Dietary antioxidant index (DAI) is a novel and reliable nutritional tool that examines the diet’s overall antioxidant capacity. Its validity was examined using serum total antioxidant capacity and malondialdehyde. OBJECTIVE:This study aimed to investigate the relationship between DAI score and odds of CHD. METHODS:In this incidence case-control study, 320 individuals with a definitive diagnosis of CHD and 320 participants without CHD or related risk factors attending the same hospitals/polyclinics were selected as the case and control groups. We estimated the DAI by summing up six standardized intakes of major dietary antioxidants, including manganese, vitamin E, A, C, selenium, and zinc. RESULTS:Modeling DAI categorized according to the median (–0.38), in multi-adjusted model showed a significant protective association with the odd of CHD (OR = 0.72; 95%CI:0.51–0.99, p-value = 0.05). Also, modeling DAI as a continuous variable in multi-adjusted models (OR = 0.94;95%CI:0.90–0.95; p-value = 0.01) showed significant results. CONCLUSION:Using the DAI to investigate the relationship between dietary antioxidants and CHD can show more realistic results than a single study of antioxidants.
Keywords: Cardiovascular disease (CVD), total antioxidant capacity (TAC), nutritional assessment, food frequency questionnaire (FFQ), malondialdehyde (MDA)
DOI: 10.3233/MNM-211503
Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 15, no. 1, pp. 103-115, 2022
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl