Effect of synbiotic supplementation on asprosin level in high fat diet-induced metabolic disorder in pregnant rats

Article type: Research Article

Authors: Naghizadeh, Mehrdad^a | Karajibani, Mansour^{b; *} | Fanaei, Hamed^{c; *} | Montazerifar, Farzaneh^{b; d; e} | Dashipour, Alireza^e

Affiliations: [a] Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [b] Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [c] Pregnancy Health Research Center, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [d] Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [e] Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Department of Food Science, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Correspondence: [*] Corresponding authors. Hamed Fanaei, PhD, Pregnancy Health Research Center, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Tel.: +98 54 33295717 20; Fax: +98 54 33295728; Postal code: 9816743181; E-mail: fanaeih@yahoo.com and Mansour Karajibani, PhD, Associate professor, Health Promotion Research Center, Nutrition Department, Medical School, Zahedan University of Medical Sciences, Zahedan, Iran. Tel.: +98 54 33295717 20; Fax: +98 54 33295728; Postal code: 9816743181; E-mail: mkarajibani@yahoo.com.

Abstract: Synbiotic supplementation can improve metabolic disorders. The aim of this study was to assess the impact of synbiotic supplementation on the levels of asprosin, lipid profile, glucose, and insulin resistance in pregnant rats fed a high-fat diet (HFD). Rats were divided into three groups: control group (fed base chow), HFD group, and HFD + synbiotic group. Levels of blood glucose, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), insulin, and asprosin levels were measured. Birth weight of offspring in the HFD + synbiotic group was significantly lower than in the HFD group. Similarly, serum asprosin, insulin, insulin resistance, TG and total cholesterol levels in the HFD + symbiotic group were significantly lower than in the HFD group. Asprosin levels had a significant and positive correlation between food intake in the first ten days of the experiment and gestation period, fasting blood sugar (FBS), TG, and homeostatic model assessment (HOMA) index. Moreover, asprosin levels had a significant and negative correlation with HDL and insulin levels. Results showed, synbiotic supplementation has beneficial effects on obese animals and improves weight gain during pregnancy, pup birth weight, FBS, insulin resistance and lipid profile. These advantages of synbiotic supplementation could be mediated by reducing serum asprosin levels.

Keywords: Asprosin, symbiotic, metabolic syndrome, pregnancy, high-fat diet

DOI: 10.3233/MNM-210595

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 15, no. 1, pp. 81-90, 2022