The differential response to intermittent fasting diet versus low calorie diet with exercise based on -866 G/A UCP2 gene variation in adults with overweight/obesity
Affiliations: Department of Nutrition and Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta, Indonesia
Correspondence:
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Corresponding author: Harry Freitag Luglio Muhammad, M.Sc, RD, Department of Health Nutrition, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Jl. Farmako, Sekip Utara, Yogyakarta, 55281, Indonesia. Tel./Fax: +62 274 547775; E-mail: harryfreitag@ugm.ac.id.
Abstract: Background:The UCP2 gene variation has been associated with the increased risk for obesity and lower response to an energy-restricted diet. Objectives:This study aimed to compare the effect of intermittent fasting diet (IFD) and low-calorie diet with exercise (LCD-ex) based on UCP2 gene variations. Methods:Subjects were adult men and women (n = 125) with body mass index between 25–40 kg/m2. During IFD, subjects were abstained from eating and drinking for 13 hours. During LCD-ex, subjects received dietary counseling for low-calorie diet and group exercise program. Anthropometric changes were compared after 4 weeks. The -866 G/A (rs659366) UCP2 gene variation was analyzed and subjects were separated into 2 groups: GG and AA+GA. Results:In GG genotype, IFD was associated with a higher weight reduction compared to LCD-ex (–1.7±0.2 vs. –0.7±0.3 kg, p = 0.016). In AA+GA genotypes, there were no differences in weight loss between IFD and LCD-ex (–1.7±0.3 vs. –1.7±0.3 kg, p = 0.967). No differences in energy intake between genotypes (all p > 0.05). Conclusions:This study shows that GG genotype of -866 G/A UCP2 was associated with a better response towards IFD compared to LCD-ex.
