Studies on DNA-binding and plasmid-cleavage of cobalt (III) mixed ligand complexes

Article type: Research Article

Authors: Shilpa, Mynam | Nagababu, Penumaka | Satyanarayana, S.

Affiliations: Department of Chemistry, Osmania University, Hyderabad 500007, Andhra Pradesh, India

Note: [] Corresponding author. Email: ssnsirasani@yahoo.com

Abstract: Mixed ligand cobalt (III) complexes of [Co(phen)2nip]3+, [Co(phen)2apip]3+, [Co(bpy)2nip]3+, [Co(bpy)2apip]3+ where [apip = 2(4-aminophenyl)imidazo[4,5f] [1,10] [phenanthroline], [nip = 2(2-napthyl) l4-midazo[4,5-f][1,10]phenanthroline] have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption (UV/Vis), emission spectroscopy, viscosity measurements, and DNA melting. The results suggest that the complexes bind to DNA via the intercalative mode with complexes 1 > 2 > 3 > 4 binding more strongly to CT DNA. Moreover, these complexes have been found to promote the photocleavage of plasmid DNA pBR322.

Keywords: cobalt (III), complexes, DNA-binding, plasmid-cleavage

DOI: 10.1080/10241220902962929

Journal: Main Group Chemistry, vol. 8, no. 1, pp. 33-45, 2009