Affiliations: Department of Chemistry, Karnatak University’s Karnatak Science College, Dharwad, Karnataka, India | Department of Chemistry, Kittel Science College, Dharwad, Karnataka, India | P.G. Department of Chemistry, Karnatak University, Dharwad, Karnataka, India
Abstract: Schiff bases derived from 5-substituted salicylidine 3-[p-(5-substituted salicylidinehydrazinocarbonyl)]phenylsydnones and their transition metal complexes with Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibilities, electronic, infrared, Proton Magnetic Resonance (PMR) (1H NMR), Fast Atomic Bombardment-(FAB)-mass spectra, Electron Spin Resonance (ESR), and thermal studies. From the above spectral studies, it is concluded that the ligands viz., 3-[p-(salicylidinehydrazinocarbonyl)]phenylsydnone (L1); p-(vanillidine hydrazinocarbonyl)]phenylsydnone (L2); and 3-[p-(5′chlorosalicylicdinehydrazinecarbonyl)]phenylsydnones (L3) act as bidentate molecules coordinating through azomethine nitrogen and phenolic oxygen. The ligands and their metal complexes have been screened in vitro for antibacterial, antifungal, and antitumor activities. The results indicate that the biological activity has increased on complexation. The Cu(II) complexes of the above-said ligands have proven to be antitumor agents toward the P388/s tumor cells at lower concentrations.
