Abstract: Gentamicin is an aminoglycoside antibiotic with known adverse side effects to the kidney and the inner ear. It is proposed that these effects result from complex formation of gentamicin with Co (1), Ni (2), Cd (3) and Sn (4). Metal coordination to gentamicin was studied by various spectroscopic techniques. The crystal system, lattice parameters, unit cell, particle size and volume were determined by XRPD. The crystallographic data of complex (2) are: Monoclinic, space groupP4/m, a = 16.67920Å, b = 12.71476Å, c = 5.2673Å, V = 1112.00Å3, α = 90, β = 95.21, γ = 90° and for complex (4): crystal system, Triclinic, space group, P1, a = 8.290549, b = 9.619387, c = 16.12853, α = 63.75208, β = 53.3017, γ = 62.28692, V = 888.68. The molecular structures of the complexes were optimized by MM2 calculations which indicated a square planar arrangement of gentamicin around the metal ions.
Keywords: aminoglycoside, gentamicin, spectra, metal binding, molecular modeling
