Affiliations: 1800 E Spring Creek Pkwy #1326, Plano, TX 75074, USA | Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India | Department of Pharmacology, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirapalli, 620021, India
Abstract: In the animal body, various electron transport chains and various enzymatic reactions either produce free radical intermediates or use free radical substrates. These free radical production have developed several mechanisms to control them. Earlier studies suggests that the Swertia chirata extract was a potent hepatoprotective drug in vivo. Since the ethanolic extract was rich in xanthones, it reduces the free radical induced lipo-peroxidation. In vivo studies on animal models have confirmed the antiradical properties of the extract. The drugs which prevent the toxic effects of free radicals are called free radical scavengers or anti oxidants. Co-enzyme Q10, Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPX) are examples of such drugs. The lethal cell injury by CCl4 results in the elevation of lipid peroxidation products, impairment in antioxidant enzyme activities. An extraction procedure is described for the isolation of xanthones from the plant S. chirata.
