A novel quinoline-based fluorescent sensor for imaging Copper (II) in living cells

Article type: Research Article

Authors: Zhou, Chen^{; *} | Liu, Heng | Zhang, Yinan

Affiliations: Research Center for Nanotechnology, Changchun University of Science and Technology, Changchun, P. R. China

Correspondence: [*] Corresponding author: Chen Zhou, Research Center for Nanotechnology, Changchun University of Science and Technology, Changchun, 130022, P. R. China. E-mail: zhouchen@cust.edu.cn.

Abstract: In this work, we synthesized a simple fluorescent molecule based on quinoline derivative. It displayed excellent sensitivity and selectivity toward copper ions. Upon addition of Cu2+, this molecule exhibited fluorescence quenching due to a fast electron transfer mechanism, the detection limit for Cu2+ of this sensor could be 6.17×10–7μmol L–1. Simultaneously, the cell imaging experiments were utilized to demonstrate its applicability in biological systems.

Keywords: Fluorescent sensor, Copper, quinoline derivative, cell-imaging

DOI: 10.3233/MGC-180248

Journal: Main Group Chemistry, vol. 17, no. 1, pp. 53-61, 2018