Synthesis of selenium containing quinoline probe for superoxide sensing and its anticancer activity study

Article type: Research Article

Authors: Salunke, Shrikrishna T.^{a; b} | Shelar, Divyesh S.^a | Salunkhe, Snehal S.^a | Singh, Pinky R.^c | Vaidya, Shashikant P.^c | Manjare, Sudesh T.^{a; *}

Affiliations: [a] Department of Chemistry, University of Mumbai, Mumbai, India | [b] Department of Chemistry, T.C. College, Baramati, India | [c] Department of Clinical Pathology, Haffkine Institute, Mumbai, India

Correspondence: [*] Corresponding author: Sudesh T. Manjare, Department of Chemistry, University of Mumbai, Mumbai, 400098, India. E-mail: sudeshmanjare@chemistry.mu.ac.in

Abstract: Herein, we have reported the highly effective use of the Knoevenagel condensation reaction to synthesize organoselenium containing quinoline-based probe. The probe was characterized by Nuclear Magnetic Resonance and Infra-Red spectroscopy and mass spectrometry. The probe selectively detects KO2 with high sensitivity over other reactive oxygen species and biothiols. Photo-induced electron transfer process is responsible for fluorescence “turn-on” event through transformation of selenide to selenoxide. The probe reacted with KO2 in less than a second with lower detection limit (0.14μM). The probe have better anticancer potency as compared to standard drug Cisplatin.

Keywords: Quinoline, BODIPY, sensor, turn-on response, selenium

DOI: 10.3233/MGC-230106

Journal: Main Group Chemistry, vol. Pre-press, no. Pre-press, pp. 1-12, 2024