Affiliations: [a] Department of Microbiology, Women University Mardan, Khyber Pakhtunkhwa, Pakistan
| [b] Department of Botany, Islamia College Peshawar, Khyber Pakhtunkhwa, Pakistan
| [c] Department of Pharmacology, Collage of Pharmacy, King Khalid University, Abha, Saudi Arabia
| [d] Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
| [e] Clinical laboratories, School of Applied Medicine Science, King Khalid University, Abha, Asir, Saudi Arabia
Correspondence:
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Corresponding author: Shah Khalid, Department of Botany, Islamia College Peshawar, 25120, Khyber Pakhtunkhwa, Pakistan. E-mail: shahkhalid@icp.edu.pk.
Abstract: Plants synthesize large amount of useful and complex products which have no obvious metabolic and growth functions. These complex materials are said to be as secondary metabolites—phytochemicals which are plants active compounds possessing the potential to inhibit diseases. The purpose of the recent study was to investigate the pharmaceutical values of the flowers of Taraxacum officinale, for antimicrobial, anti-pellicle and anti-biofilm properties. Metanolic extracts with chloroform and n-hexane fractions against selected different bacterial (E.coli, P.aeruginosa, S.aureus, S.typhi) and fungal (F.oxysporum, A.niger, A.alternata, A.Terreus) strains were tested and GC-MS, FTIR and HPLC techniques, for detection of various secondary metabolites which are responsible for these activities, were performed. In antimicrobial assay, the result of the methanolic extract and fractions of the flowers was found to be effective against the tested bacterial and fungal strains. The GC-MS and FTIR analysis of chloroform fractions of T. officinale flowers reported the presence of a wide range of phytochemicals and secondery metabolites liable for the biological activities that can be purified in future for the synthesis of noval improved and valuable pharmaceutical products.
