Affiliations: [a] Department of Pharmacy, Traditional Chinese Medical Hospital of Huangdao District, Qingdao, Shandong, China
| [b] Department of Pulmonary Diseases, Huangdao District Chinese Medicine Hospital, Qingdao, Shandong, China
| [c] Qingdao Center for Disease Control and Prevention, Qingdao, Shandong, China
| [d] Department of Health Management, Chinese Medicine Hospital of Huangdao District, Qingdao, Shandong, China
Correspondence:
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Corresponding author: Qiu-Lian Cui, Department of Health Management, Chinese Medicine Hospital of Huangdao District, Qingdao, Shandong, China. E-mail: xumeihua2020@126.com.
Abstract: In the current study, using a semi-flexible quadritopic N-donor ligand, 5,5′-bipyrimidine (bpym), a new azide-based coordination polymer, [Co(bpym)(N3)2]n (1), was synthesized and structurally characterized via the single crystal X-ray diffraction along with the elemental analysis. Its treatment activity on the chronic obstructive pulmonary disease (COPD) would be evaluated and the related mechanism was explored. Firstly, the ELISA (enzyme linked immunosorbent assay) detection assay was performed and the levels of the inflammatory cytokines were measured. In addition to this, the NF-κB signaling pathway activation in the lung epithelial cells was measured with the real time RT-PCR (reverse transcription-polymerase chain reaction). Both six-membered rings containing nitrogen and the azide group on the designed drug molecule were confirmed by molecular docking simulation to have activities to the NF-kappaB.
