Novel preparation and spectral investigation of monometallic transition metal Schiff base complexes (Zn, Cu, Mn, Co) as bacteria and fungus inhibitors

Article type: Research Article

Authors: Pervaiz, M. | Yousaf, M. | Sagir, M. | Naz, M.Y.^; | Mushtaq, M. | Ullah, S. | Chatha, S.A.S.

Affiliations: Department of Chemistry, Government College University, Faisalabad, Pakistan | Department of Chemical Engineering, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, Tronoh, Perak, Malaysia | Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, Tronoh, Perak, Malaysia | Department of Physics, University of Agriculture, Faisalabad, Pakistan

Note: [] Corresponding author: M. Pervaiz, Department of Chemistry, Government College University, Faisalabad, Pakistan. Tel.: +92 345 6570121; E-mail: mpbhatti786@gmail.com

Note: [] Corresponding author: M. Sagir, Department of Chemical Engineering, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, Tronoh, Perak, Malaysia. Tel.: +60 13 4590681; E-mail: sagir.utp@gmail.com

Abstract: In this research, a series of monometallic complexes has been employed individually against a series of bacterial and fungal strains just to check the enhanciablity of biological activities of the synthesized monometallic complexes when compared with the parental synthesized ligand derived by the condensation reaction of phenyl hydrazine with salicylaldehyde (2-hydroxylphenylidene-N-phenylamino-imine). The bacterial strains used were Escheria coli, Staphylococcus aureus and Bacillus Subbtilis and Escheria coli. Similarly, fungal strains used were Aspergillus niger, Alternaria alternate and Aspergillus flavus for the purpose to check the capability of the compound 1, 2, 3, 4, and 5 as antibactrial and antifungicides. The results showed that the monometallic complexes are more effective against bacterial and fungal strains than the ligand. The lignad was further reacted indvidually with series of transition metals including Zn (II), Co (II), Mn (II) and Cu (II) (Bis(2-[-(2-phenylhydrazinylidene)methyl]phenolato)M(II)) where M = Zn, Co, Mn, Cu. The ligand was analysed by different spectroscopic tools as FT-IR, MS and NMR while the complexes were characterized by FT-IR and XRD.

Keywords: Schiff base, phenylhydrazine, salicylaldehyde, transition metals, tetra component solvent system, bacterial strains, fungal strains

DOI: 10.3233/MGC-140128

Journal: Main Group Chemistry, vol. 13, no. 2, pp. 129-145, 2014