On the Scent of Dandelion Dendrimers. Part IV. Molecular Modeling of Cyclophosphazenic Dandelion Dendrimers Up to the Fourth Generation

Article type: Research Article

Authors: Sournies, François | Crasnier, François | Vidal, Christiane | Labarre, Marie-Christine | Labarre, Jean-François

Affiliations: Institut de Chimie Moléculaire Paul Sabatier, Laboratoire Structure & Vie et Service Commun Informatique Chimie, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex (France)

Note: [] Corresponding author.

Abstract: We recently reported on the neat synthesis of 3-dimensional, 6-functional cyclophosphazenic cores through a regiospecific peraminolysis of N3P3C16 by long-chain diamines on suitable solid supports. Preparation of spherical dendrimers (up to the eighth generation) from such cores was achieved through alternate additions of N3P3Cl5 flagstones (5-fold multiplier) and of diamino tentacles (linker). The eighth generation possesses 2,343,750 terminal (P-C1) functions (M 228,977,179), which are suitable for further nucleophilic substitutions. Molecular modeling shows that the compactness of these dendrimers is extremely low, conferring to these huge monomers a noticeable vacuity for accomodation of host moieties.

DOI: 10.1080/13583149612331338445

Journal: Main Group Chemistry, vol. 1, no. 2, pp. 207-218, 1996