Mechanistic aspects of oxidation of loop diuretic drug furosemide by Ag(III) periodate complex in alkali media: A kinetic approach

Article type: Research Article

Authors: Malode, Shweta J. | Shetti, Nagaraj P. | Nandibewoor, Sharanappa T.

Affiliations: P.G. Department of Studies in Chemistry, Karnatak University, Dharwad, India

Note: [] Corresponding author: Sharanappa T. Nandibewoor, P.G. Department of Studies in Chemistry, Karnatak University, Dharwad 580 003, India. Tel.: +91 836 2770524; Fax: +91 836 2747884; E-mail: stnandibewoor@yahoo.com

Abstract: The kinetics of oxidation of a loop diuretic drug furosemide (Fur) by diperiodatoargentate(III) (DPA) has been investigated spectrophotometrically in alkaline medium at a constant ionic strength of 0.20 mol dm−3. The stoichiometry was 1 : 2 (Fur: DPA). The order of the reaction with respect to [DPA] was unity while the order with respect to [Fur] was less than unity over the concentration range studied. The rate increased with increase in [OH−] and decreased with increase in [IO4−]. The oxidation products were identified as 2-(4-carboxy-2-oxo-but-3-enylamino)-4-chloro-5-sulfamoyl-benzoic acid and Ag(I). The reaction constants involved in the different steps of the reaction mechanism were calculated. Kinetic experiments suggest that [Ag(H2IO6)(H2O)2] is the reactive silver(III) species.

Keywords: Furosemide, diperiodatoargentate(III), oxidation, kinetics

DOI: 10.3233/MGC-2011-0050

Journal: Main Group Chemistry, vol. 10, no. 3-4, pp. 215-227, 2011