Affiliations: Department of Pure and Applied Chemistry,
M.D.S.University, Ajmer, India | Deparment of Medicinal Chemistry, Hygia Institute of
Pharmaceutical Education and Research, Lucknow, India
Note: [] Corresponding author: Kishan G. Ojha, Department of Pure and
Applied Chemistry, M.D.S.University, Ajmer, India. E-mail:
pareekpawan@ymail.com
Abstract: A series of 2,4,6-trisubstituted 1,3,5-tris (benzothiazol-2-yl)
hexahydro-1,3,5-triazine derivatives (3) have been synthesized by
condensation of substituted benzothiazoles with 2,4,6-trisubstituted
1,3,5-trioxane by conventional as well as microwave irradiation (solvent free
and solid support) methods. All compounds were tested for antiproliferative
activity and entomological activity. The microwave irradiation technique gives
better yield and reaction completion in a shorter period of time. Among solid
supported microwave irradiation better yields are obtained with acidic alumina
as compared to silica, neutral alumina and basic alumina.The results of
biological activities prompted us that change in substitution pattern in
benzothiazolyltriazine derivatives may cause marked effect on their
antiproliferative activity.
