The changes of HRV in refractory epilepsy: The potential index to predict the onset of epilepsy in children

Article type: Research Article

Authors: Gong, Xuehao^{a; 1} | Mao, Xuhua^{b; c; 1} | Chen, Yan^{d; 1} | Huang, Leidan^{a; b} | Liu, Weizong^a | Huang, Xian^{a; e} | Tan, Zheng^f | Wang, Xianming^c | Wu, Wanqing^g | Chen, Qian^{f; *} | Li, Rong^{c; *}

Affiliations: [a] Department of Ultrasound, The Second People’s Hospital of Shenzhen, Shenzhen, Guangdong, China | [b] Guangzhou Medical University, Guangzhou, Guangdong, China | [c] Department of Thyroid and Breast Surgery, The Second People’s Hospital of Shenzhen, Shenzhen, Guangdong, China | [d] Department of Electroencephalogram Room, Shenzhen Children’s Hospital, Shenzhen, Guangdong, China | [e] Anhui Medical University, Hefei, Anhui, China | [f] Department of Pediatric Neurosurgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong, China | [g] Research center for Biosensors and Medical Instruments, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China

Correspondence: [*] Corresponding author: Qian chen, Shenzhen Children’s Hospital, 7019 Yi Tian Street, Tian Fu District, Shenzhen 518000, China. Tel.: +86 18200996295; Fax: +86 10 83290126; E-mail: chenqian68@126.com.

Correspondence: [*] Corresponding author: Rong Li, The Second People’s Hospital of Shenzhen, 2003 Sun Gang West Street, Fu Tian District, Shenzhen 518000, China. Tel.: +86 13066986913; Fax: +86 10 83775026; E-mail: 13066986913li@163.com.

Note: [1] This authors contributed equally to this work.

Abstract: In this study, we examine the potential of heart rate variability (HRV) as an efficient tool for predicting the onset of epilepsy in children. We totally collected 53 seizures EEG and ECG data using Video - EEG - ECG monitoring system. We then separated the ECG data into three segments: ten-minute before onset of each seizure, five-minute before onset of each seizure, and five-minute from the onset of each seizure. After the HRV parameters in all segments were calculated, we compared the differences between pre-ictal period and ictal period. We found that the values of meanHR, LF and LF/HF were greater in onset period. And the values of meanRR and the HF were less in ictal period. And it presented the similar changes when seizures occurred in the daytime and seizures occurred in the nighttime. In brief, we found that the sympathetic nervous system was under a more active status during onset period. We speculated that the HRV parameters such as the LF, HF or LF/HF could have potential to predict the seizures in children with epilepsy.

Keywords: Seizure, HRV, children

DOI: 10.3233/XST-160558

Journal: Journal of X-Ray Science and Technology, vol. 24, no. 2, pp. 309-317, 2016