Affiliations: [a] Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China | [b] Tsinghua-Peking Center for Life Sciences, Beijing, China | [c] Center for Biomedical Imaging Research, Tsinghua University, Beijing, China
Correspondence:
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Corresponding authors: Fei Liu, Jianwen Luo, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. E-mail:luo_jianwen@tsinghua.edu.cn,liufei13@tsinghua.edu.cn
Abstract: The present full-angle, free-space fluorescence molecular
tomography (FMT) system uses a step-by-step strategy to acquire
measurements, which consumes time for both the rotation of the object and
the integration of the charge-coupled device (CCD) camera. Completing the
integration during the rotation is a more time-efficient strategy called
synchronous data acquisition. However, the positions of sources and
detectors in this strategy are not stationary, which is not taken into
account in the conventional reconstruction algorithm. In this paper we
propose a reconstruction algorithm based on the finite element method (FEM)
to overcome this problem. Phantom experiments were carried out to validate
the performance of the algorithm. The results show that, compared with the
conventional reconstruction algorithm used in the step-by-step data
acquisition strategy, the proposed algorithm can reconstruct images with
more accurate location data and lower relative errors when used with the
synchronous data acquisition strategy.
Keywords: Fluorescence, image reconstruction, synchronous data acquisition, tomography
