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Article type: Research Article
Authors: Li, Jina; 1 | Yin, Weib; 1 | Wang, Yuanjuna; *
Affiliations: [a] School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China | [b] Department of Radiology, Changhai Hospital, The Naval Military Medical University, Shanghai, China
Correspondence: [*] Corresponding author: Yuanjun Wang, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. E-mail: yjusst@126.com.
Note: [1] These authors contribute equally.
Abstract: BACKGROUND:Pancreatic cancer is a highly lethal disease. The preoperative distinction between pancreatic serous cystic neoplasm (SCN) and mucinous cystic neoplasm (MCN) remains a clinical challenge. OBJECTIVE:The goal of this study is to provide clinicians with supportive advice and avoid overtreatment by constructing a convolutional neural network (CNN) classifier to automatically identify pancreatic cancer using computed tomography (CT) images. METHODS:We construct a CNN model using a dataset of 6,173 CT images obtained from 107 pathologically confirmed pancreatic cancer patients at Shanghai Changhai Hospital from January 2017 to February 2022. We divide CT slices into three categories namely, SCN, MCN, and no tumor, to train the DenseNet201-based CNN model with multi-head spatial attention mechanism (MSAM-DenseNet201). The attention module enhances the network’s attention to local features and effectively improves the network performance. The trained model is applied to process all CT image slices and finally realize the two categories classification of MCN and SCN patients through a joint voting strategy. RESULTS:Using a 10-fold cross validation method, this new MSAM-DenseNet201 model achieves a classification accuracy of 92.52%, a precision of 92.16%, a sensitivity of 92.16%, and a specificity of 92.86%, respectively. CONCLUSIONS:This study demonstrates the feasibility of using a deep learning network or classification model to help diagnose MCN and SCN cases. This, the new method has great potential for developing new computer-aided diagnosis systems and applying in future clinical practice.
Keywords: Pancreatic neoplasm, pancreatic tumor classification, Convolutional Neural Network, transfer learning, computed tomography (CT), computer-aided diagnosis (CAD)
DOI: 10.3233/XST-221281
Journal: Journal of X-Ray Science and Technology, vol. 31, no. 1, pp. 167-180, 2023
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