Challenges in the diagnosis of calyceal diverticulum: A report of two cases and review of the literature

Article type: Research Article

Authors: Zhang, Zejian^{a; 1} | Zhang, Yixiang^{b; 1} | Wang, Xisheng^{a; *} | Chen, Dong^a | Peng, Naixiong^a | Chen, Jicheng^a | Bleyer, Anthony^c | Wang, Qinjun^a | Liu, Yunfei^a | Zhang, Yuanyuan^{d; *}

Affiliations: [a] Department of Urology, Shenzhen Longhua District Central Hospital, Guangdong, Shenzhen, China | [b] Department of Urology, Shenzhen People’s Hospital, Guangdong, Shenzhen, China | [c] Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC, USA | [d] Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Correspondence: [*] Corresponding authors: Xisheng Wang, Department of Urology, Shenzhen Longhua District Central Hospital, Guangdong, Shenzhen, China. E-mail: JHYS120@21cn.com and Yuanyuan Zhang, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. E-mail: yzhang@wakehealth.edu.

Note: [1] The authors contributed equally to this work.

Abstract: Background:Calyceal diverticula outpouchings that occur rarely in the upper collecting system of the kidney and is often difficult to detect. In this study, we present two cases of calyceal diverticula and discuss their clinical characteristics and radiologic features. Patients and methods:In the presented two cases, we applied several imaging examinations, including delayed intravenous pyelography, retrograde pyelography and axial computerized tomographic (CT) scanning of the kidneys with and without contrast. Serum creatinine levels in fluid withdrawn from the diverticula were found to be significantly higher than the simultaneous serum creatinine levels. Intravenous injection of methylene blue through a ureteral catheter was also aided in the diagnosis. Calyceal diverticulum neck dilatation was performed through a percutaneous nephroscope. ResultsThe two cases were diagnosed preoperatively and the operation was successful performed. The nephrostomy tube was removed seven days after surgery without complications. CT scans of the kidney after six months showed that the size of the calyceal diverticulum of two patients were considerably smaller than pre-surgery. There were no reports of pain in the lumbar region or other discomfort. Comments:Diagnosis of calyceal diverticulum mainly depend on a variety of imaging examinations, including the delayed intravenous pyelography, retrograde pyelography, and kidney CT plain scan plus enhanced scan. If the patient cannot be diagnosed by above methods, cyst fluid can be aspirated percutaneously to measure the preoperative creatinine level. If it is significantly higher than the serum creatinine level, the cyst fluid is considered urine, which can assist in the diagnosis of calyceal diverticulum. A ureteral catheter should also be inserted before operation namely, intravenous injection of methylene blue through a ureteral catheter is helpful for diagnosis. The choice of surgical treatment is based on the size and location of calyceal diverticulum and clinical manifestations.

Keywords: Calyceal diverticula, renal cyst, diagnosis, creatinine

DOI: 10.3233/XST-190549

Journal: Journal of X-Ray Science and Technology, vol. 27, no. 6, pp. 1155-1167, 2019