Affiliations: Department of Biomedical Engineering, Peking
University, Beijing, China | Department of Biomedical Engineering, Tsinghua
University, Beijing, China
Note: [] Corresponding authors: Qiushi Ren, Changhui Li, Department of
Biomedical Engineering, Peking University, Beijing 100871, China. E-mail:
chli@pku.edu.cn; renqsh@coe.pku.edu.cn
Abstract: Nowadays multi-modality imaging has gained great interest in biology
research by offering complementary information. In this paper, a modularly
designed fluorescence molecular tomography (FMT) system has been developed,
which can be not only used as a standalone imaging device, but also feasibly
integrated with other imaging modalities, such as X-ray computed tomography
(X-CT), single photon emission computed tomography (SPECT) and positron
emission tomography (PET), to perform multi-modality imaging in a sequential
manner. The system rotates the CCD camera and the excitation light source in
the vertical plane, while the animal is stationed on a horizontally moveable
transparent animal holder at its natural prone position. FMT and other imaging
modalities are co-registered automatically. Phantom and animal experiments have
been carried out to demonstrate the performance of the system. The accurate
results show that this innovative flexible FMT system has a great potential to
be a powerful tool for the study of small animal disease models.
