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Effect of local mild hypothermia on regional cerebral blood flow in patients with acute intracerebral hemorrhage assessed by ^{99m}Tc-ECD SPECT imaging

Article type: Other

Authors: Su, Xinhui; | Zheng, Kunmu | Ma, Qilin | Huang, Jingxiong | He, Xiaojiang | Chen, Guibing | Wang, Weixing | Su, Fu | Tang, Hui | Wu, Hua | Tong, Suijun

Affiliations: Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen, Fujian, China | Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China | Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

Note: [] Corresponding authors: Xinhui Su, Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian, China. E-mail: suxinhuii@163.com; Suijun Tong, Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian, China. E-mail: tsjneurology@126.com

Keywords: Local mild hypothermia, regional cerebral blood flow, intracerebral hemorrhage, SPECT imaging

DOI: 10.3233/XST-140473

Journal: Journal of X-Ray Science and Technology, vol. 23, no. 1, pp. 101-109, 2015

Received 5 May 2014
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Accepted 28 October 2014
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Published: 2015
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Abstract

OBJECTIVE: This study aimed to observe the effect of local mild hypothermia on regional cerebral blood flow (rCBF) after acute intracerebral hemorrhage (ICH) and to evaluate its relation to clinical outcome in patients with ICH.

METHODS: 36 CT proven ICH patients with Glasgow coma scale (GCS) score of 5 or more were randomly assigned to 2 group: local mild hypothermia with conventional mannitol (Group A) or conventional mannitol (Group B). SPECT study was performed at day 7 after therapy. The SPECT images were semi-quantitatively analyzed, and the radioactivity ratios of lesion to normal tissue (L/NT) were calculated. National Institutes of Health Stroke Scale (NIHSS) were used in evaluation at days 14 and 21 after therapy.

RESULTS: There were significant differences in NIHSS score at days 14 and 21, and the L/NT ratios between the groups A and B (P < 0.05). Based on GCS, more patients in the group A showed favorable outcomes than patients in the group B (P < 0.05). Furthermore, the L/NT ratios significantly increased in patients with favorable outcomes compared to poor outcomes. Changes in NIHSS score at days 14 and 21 were closely negatively correlated with the L/NT ratios in the groups A and B (r= −0.58, −0.61, and −0.52, −0.75, respectively, P < 0.05).

CONCLUSION: Local mild hypothermia could significantly increase rCBF and improve clinical outcome in ICH patients as evaluated by [TeX:] ^{99m}Tc-ECD SPECT study.

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