Affiliations: Department of Urology, Beijing Friendship Hospital,
Capital Medical University, Beijing, China | Center for Cancer Genomics, Wake Forest University
School of Medicine, Winston-Salem, NC, USA | Department of Pathology, Beijing Friendship Hospital,
Capital Medical University, Beijing, China | Institute for Regenerative Medicine, Wake Forest
University, Winston-Salem, NC, USA
Note: [] Corresponding authors: Ye Tian, Department of Urology, Beijing
Friendship Hospital, Capital Medical University, 95 YongAn Road, Xicheng
District, Beijing 100050, China. E-mail: 83432350@qq.com. Yuanyuan Zhang,
Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC
27157, USA. E-mail: yzhang@wakehealth.edu
Abstract: The appendiceal diseases, particularly appendicitis, are the most
common disorders in the digestive system localized at the right lower quadrant
area. However, appendiceal carcinoma with vesico-appendiceal fistula is a rare
clinical phenomenon. Lacking specific symptoms, appendiceal carcinomas with
fistula formations are often misdiagnosed as acute appendicitis cases. The
purpose of this study is to increase awareness of appendiceal neoplasms and
appendicovesical fistulas. We reported our experiences in three complex cases
related to digestive and urological systems, and reviewed the literature on
diagnosis with various X-ray imaging techniques for this lesion. In this
report, the first case failed to be diagnosed. The other two patients with
appendicovesical fistulas secondary to appendiceal adenocarcinomas were
successfully detected with computed tomography (CT) and cystoscopy. The
patients recovered after right hemicolectomies and en bloc partial cystectomies
and survived without tumor metastasis up to 7-year follow-up. In conclusion, a
combined use of CT imaging and endoscopy techniques provides an accurate
diagnostic alternative for appendicovesical fistula secondary to appendiceal
adenocarcinoma.
