A CT-analogous scheme for time-domain diffuse fluorescence tomography

Article type: Research Article

Authors: Gao, Feng^; | Li, Jiao | Zhang, Wei | Yi, Xi | Wang, Xin | Zhang, Limin^; | Zhou, Zhongxing^; | Zhao, Huijuan^;

Affiliations: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, China | Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin, China

Note: [] Corresponding author: Feng Gao, College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China. E-mail: gaofeng@tju.edu.cn

Abstract: A fiber-based non-contact scheme of the time-domain diffuse fluorescence yield and lifetime tomography is described that combines the time-correlated single photon counting technique for high-sensitive, time-resolved detection and CT-analogous configuration for large data-set collection. A pilot validation of the methodology is performed for two-dimensional scenarios using simulated and experimental data. The results demonstrated the efficacy of the proposed scheme in improving the image quality.

Keywords: Diffuse fluorescence tomography, time-resolved detection, CT-scanning configuration, image reconstruction technique, photon migration

DOI: 10.3233/XST-2012-0321

Journal: Journal of X-Ray Science and Technology, vol. 20, no. 1, pp. 91-105, 2012