Source intensity optimization in quantitative three-dimensional diffuse optical tomography

Article type: Research Article

Authors: Li, Changqing | Jiang, Huabei

Affiliations: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, USA

Note: [] Corresponding author. Tel.: +1 352 392 7943; Fax: +1 352 392 9791; E-mail: hjiang@bme.ufl.edu

Abstract: We present a method that optimizes the source intensity distribution in three-dimensional (3D) diffuse optical tomography (DOT). We evaluate this method using a series of phantom experiments where different contrast levels between the target and background are considered. With the new method, while the quality of both absorption and scattering images is quantitatively improved, the improvement in absorption image reconstruction is especially substantial: a relative error of less than 0.95% for recovered peak value in the target region is achieved for high contrast case and of less than 18.0% for low contrast case.

Keywords: Diffuse optical tomography, calibration, three dimensional optical imaging, source intensity optimization, Near Infrared

Journal: Journal of X-Ray Science and Technology, vol. 14, no. 4, pp. 257-272, 2006